Neurobiological Interactions Between Stress and the Endocannabinoid System

Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.

Endocannabinoid signaling is distributed throughout the brain, regulating synaptic release of both excitatory and inhibitory neurotransmitters. The presence of endocannabinoid signaling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of s...

The Endocannabinoid System and Stress

Introduction One of the environmental factors that precipitates and exacerbates mental illnesses, including depression, anxiety disorders, and substance abuse, is repeated life stress. For example, homotypic stressors that occur on a daily basis, such as poverty or medical problems, are associated with increased depressive symptoms [1]. Not everyone exposed to stress has pathological consequenc...

Motion Sickness, Stress and the Endocannabinoid System

BACKGROUND A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel. Motion sickness can be extremely stressful but the neurobiologic mechanisms leading to motion sickness are not clear. The endocannabinoid system (ECS) represents an important neuromodulator of stress and N&V. Inhibitory effects of th...

Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance Short title: Endocannabinoid system and stress

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are reports suggesting this possibility. Additionally, the individual role of the endocannabinoid and kyn...